Wednesday , January 20 2021

Obesity is a high-risk cardiorenal profile in young people with type 1 diabetes

medwireNews: Adolescents with type 1 diabetes who are obese have a cardiorenal risk profile similar to that of their peers with type 2 diabetes, the researchers say.

“Thus, although the data previously indicated that the long-term consequences of the onset of youth [type 2 diabetes] found to predict a higher cardiovascular and renal risk than in young people [type 1 diabetes], this gap may decrease if obesity continues to increase [type 1 diabetes]”, – the command writes Diabetes care.

“Thus, close attention to weight loss strategies and lifestyle management is critical for young people with [type 1 diabetes] help reduce risk for the future [cardiovascular disease]. “

Indeed, Kristen Nado (Colorado Children’s Hospital and University of Colorado, Anschutz Medical Center, Aurora, USA) and colleagues found that obese with type 1 diabetes had the highest mean systolic blood pressure of all groups, averaging 124 mm Hg. St. .

The team studied 284 adolescents aged 12–21 years, including 135 with type 1 diabetes and 59 with type 2 diabetes, plus 43 lean and 47 obese adolescents without diabetes. All subgroups with diabetes had the same level of glycated hemoglobin.

Mean systolic blood pressure in the type 2 diabetes group was only slightly lower than in obese adolescents with type 1 diabetes, 121 mm Hg. Century, but only 12% of this group had hypertension, compared with 44% of obese adolescents with type 1 diabetes. . Hypertension was also common in overweight participants with type 1 diabetes – 26%, with a mean systolic blood pressure of 123 mm Hg.

By comparison, 11% of obese participants without diabetes had hypertension, although mean systolic blood pressure was lower than that of adolescents with diabetes at 116 mm Hg.

Diastolic blood pressure, mean blood pressure, and heart rate were also highest in participants with type 1 diabetes and obesity, with values ​​in the overweight group being the same or only slightly lower, and in all cases higher than in adolescents with type 2 diabetes. . and participants in obesity without diabetes.

In the type 1 diabetes group, all blood pressure plus heart rate significantly correlated with BMI.

Renal function was worst in participants with type 2 diabetes, 31% and 33% with microalbuminuria and hyperfiltration, respectively. However, in all participants with type 1 diabetes, the level of microalbuminuria was higher than in the control groups without diabetes, by 12–18% versus 0–3%, and renal parameters did not correlate with BMI in this group.

“These results confirm the conclusion that [type 1 diabetes] unequivocally exposes people to the risk of complications, including cardiovascular dysfunction, regardless of [glycated hemoglobin] and BMI “, – sums up the team.

medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2021 Springer Healthcare Ltd, part of the Springer Nature Group

Diabetes care 2021; doi: 10.2337 / dc20-1879

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