Team Chilean researchers has achieved promising successes in Russia fight against Alzheimer's disease, after the connection between the activation of the brain pathway and the correct metabolism of sugars in the brain.
Work headed by doctors Nibaldo Inestros and Pedro Cisternas, The Center for the Aging and Revival of the Catholic University (CARE Chile UC) and developed on animal models, have reached improve cognitive abilities and memory in mice and was recently published in Journal Neurochemestry, reportedly Ephesus researchers.
Learning, learning and sense of humor are cognitive abilities that require high energy consumption in the brain, and proper use of sugars in this organ can now be modulated in the laboratory through this study.
Researchers have been able to determine the importance of activating a Brain Path called Wnt in the metabolism of glucose, the fundamental process for neurons and brain activity.
Experiment in transgenic animals
Experiments developed in transgenic animal models are specifically sought slow or slow Alzheimer's, the most common disease of aging that affects about 18 million people in the world and is the fourth cause of death on the planet.
Studies "indicate that Activating the Wnt pathway stimulates glucose metabolism, mainly in neurons, is a very important process in the brain, an organ that needs a large amount of glucose and energy for its proper functioning, especially in memory and learning regions such as cortex and hippocampus " , – Dr. Chistersnas explained.
The brain, according to him, is 2% of body weight, but requires about 20% oxygen and 25% ATP (a fundamental nucleotide in obtaining cellular energy) of the human body.
Due to the study, the correct treatment of sugar in the brain can be modulated in the laboratory. (Photo: Pixabay)
ATP, which is emphasized by tanks, is a molecule of energy occupied by cells for their livelihoods, and in this context an important aspect is that glucose metabolism decreases in virtually all neurodegenerative diseases such as Alzheimer's, Parkinson's and Gentinton's " stemmed from a decrease in brain's ability to use glucose. "
At the same time, Wnt is a mechanism formed by proteins that is associated with processes of brain formation, synapse, neuron interaction, memory and learning, and research has explored its leading role in Alzheimer's and other diseases. failures, as well as some strategies for its activation.
Last, to prevent damage and restore contact between neurons.
Reconnect between brain cells
Dr. Nibaldo Inetros, National Science Award, explained that the Alzheimer's neurons suffer from deterioration due to the accumulation of an insoluble protein type called beta-amyloid, which interrupts the signaling function that connects the neurons with one.
In this context saving the way Wnt "can restore contact between brain cells and prevent injuries.For all this, it's important for us to find the compounds that activate it and which can be transformed into possible methods of treating this pathology, "he said.
"In our latest publication, we noticed that when we activate the Wnt pathway in our models, the cognitive responses of these animals are improving, and the glucose metabolism is stimulated, apart from all the functions we studied earlier," he said.
But "when at the same time we are introducing an glucose uptake inhibitor, this protective effect is lost, which means that activating the road contributes to improvement, but it is also there depends on the use of glucose and the generation of ATP"
Against this backdrop Researchers are developing various strategies for activating the Wnt signal pathto help improve the condition or progression of Alzheimer's disease.
"We want to develop therapy from molecules that generate activation of this pathway and thus contribute to the project for patients with Alzheimer's disease, which generally prevents the loss of memory. It can have a tremendous impact on the affected people and their family environment, "said Dr. Cisternas.